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dc.date.accessioned 2024-11-04T15:58:28Z
dc.date.available 2024-11-04T15:58:28Z
dc.date.issued 2018-12-14
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/172505
dc.description.abstract A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research. en
dc.language en es
dc.subject 1,4-Benzodiazepines es
dc.subject 2-Chloro-N-(2-nitrobenzyl)acetamides es
dc.subject Iron-ammonium chloride reduction es
dc.subject 2-Nitrobenzylamines es
dc.title Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin- 3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides en
dc.type Articulo es
sedici.identifier.other https://doi.org/10.1016/j.tetlet.2018.12.029 es
sedici.creator.person Sasiambarrena, Leandro Daniel es
sedici.creator.person Barri, Iván Alejandro es
sedici.creator.person Fraga, Guido Gustavo es
sedici.creator.person Bravo, Rodolfo Daniel es
sedici.creator.person Ponzinibbio, Agustín es
sedici.subject.materias Química es
sedici.description.fulltext true es
mods.originInfo.place Centro de Estudios de Compuestos Orgánicos es
sedici.subtype Articulo es
sedici.rights.license Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
sedici.rights.license Creative Commons Attribution 4.0 International (CC BY 4.0)
sedici.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
sedici.rights.uri http://creativecommons.org/licenses/by/4.0/
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Tetrahedron Letters es
sedici.relation.journalVolumeAndIssue vol. 60, no. 3 es


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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) Excepto donde se diga explícitamente, este item se publica bajo la siguiente licencia Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)