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dc.date.accessioned 2012-05-17T20:35:41Z
dc.date.available 2012-05-17T20:35:41Z
dc.date.issued 2012
dc.identifier.uri http://sedici.unlp.edu.ar/handle/10915/18145
dc.description.abstract 7-Enthyl-4’-phenylsulfonyldaidzein (EPD 3), a potential prodrug for daidzein, was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient LogP, and hydrolysis kinetics than its original form. The LogP value (3.07) and the half-life of the hydrolysis value (24.06 h) show that its oral bioavailability is possibly improved evidently compared with that of daidzein. These results indicate that EPD can be considered a potential prodrug for daidzein. es
dc.format.extent 326-330 es
dc.language en es
dc.subject daidzein sulfonate; crystal structure; prodrug; hydrolysis; partition coefficient es
dc.subject Farmacología es
dc.subject Prodrogas es
dc.subject Preparaciones Farmacéuticas es
dc.title Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate es
dc.type Articulo es
sedici.identifier.uri http://www.latamjpharm.org/resumenes/31/2/LAJOP_31_2_2_5.pdf es
sedici.identifier.issn 0326-2383 es
sedici.creator.person Peng, You es
sedici.creator.person Li, Xue-Qin es
sedici.creator.person Hu, Xiao-Ming es
sedici.subject.materias Farmacia es
sedici.description.fulltext false es
mods.originInfo.place Colegio de Farmacéuticos de la Provincia de Buenos Aires es
sedici.subtype Comunicacion es
sedici.description.peerReview peer-review es
sedici.relation.journalTitle Latin American Journal of Pharmacy
sedici.relation.journalVolumeAndIssue vol. 31, no. 02


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